517 research outputs found
Genetic, Pathophysiological and Clinical Aspects of Nephrocalcinosis
Nephrocalcinosis describes the ectopic deposition of calcium salts in the kidney parenchyma. Nephrocalcinosis can result from a number of acquired causes, but also an even greater number of genetic diseases, predominantly renal, but also extra-renal. Here we provide a review of the genetic causes of nephrocalcinosis, along with putative mechanisms, illustrated by human and animal data
Calibration of stakeholder influence in the UK higher education sector
Peer reviewedPublisher PD
Prison officer self-legitimacy and support for rehabilitation in Ghana
Legitimacy refers to the moral recognition of power, and prison legitimacy remains a principal issue for prison researchers and managers. However, the prison legitimacy literature tends to focus on the views held by individuals in custody. Research on prison officer Self-Legitimacy â that is, the powerholdersâ belief that the authority vested in them is morally right â remains scanty. Drawing on data from a survey of 1,062 prison officers in Ghana, this study examined both the correlates of prison officer Self-Legitimacy and the links between Self-Legitimacy and Support for Rehabilitation of individuals in custody. The results of multivariate analyses showed that having good Relations with Colleagues and being treated fairly by supervisors enhance prison officersâ Self-Legitimacy. In turn, Self-Legitimacy was found to increase officersâ Support for Rehabilitation. Finally, perceived Fair Treatment by Supervisors and positive Relations with Individuals in Custody were associated with increased Support for Rehabilitation. The implications of these findings are discussed
The influence of the political environment and destination governance on sustainable tourism development: a study of Bled, Slovenia
In the context of sustainable tourism development, there are many studies about the exchange process between residents and tourism, yet this issue is practically unexplored with respect to the political environment of tourism. Therefore, this paper introduces and posits that the political environment is a necessary enabler for implementing sustainable tourism. The authors extend the established three-pillar sustainability concept by adding in the political dimension. Then they surveyed how residents' positive and negative perceptions of tourism impacts determine their satisfaction with life in the tourism destination and thus their support for tourism in their community. The model was empirically tested within the context of the long-established Alpine destination of Bled in Slovenia. The findings confirm the importance of the political environment and question the sustainability of Bled's tourism development. It is suggested that the community has relatively weak destination governance due to the underdeveloped political environment. The survey expands and deepens the tourism sustainability debate by adding in the political environment and how it relates to the emerging growth of research on destination governance. The proposed model can be adapted and applied to any destination in order to improve its governance, including the implementation of sustainable tourism development
Corporate Security Responsibility: Towards a Conceptual Framework for a Comparative Research Agenda
The political debate about the role of business in armed conflicts has increasingly raised expectations as to governance contributions by private corporations in the fields of conflict prevention, peace-keeping and postconflict peace-building. This political agenda seems far ahead of the research agenda, in which the negative image of business in conflicts, seen as fuelling, prolonging and taking commercial advantage of violent conflicts,still prevails. So far the scientific community has been reluctant to extend the scope of research on âcorporate social responsibilityâ to the area of security in general and to intra-state armed conflicts in particular. As a consequence, there is no basis from which systematic knowledge can be generated about the conditions and the extent to which private corporations can fulfil the role expected of them in the political discourse. The research on positive contributions of private corporations to security amounts to unconnected in-depth case studies of specific corporations in specific conflict settings. Given this state of research, we develop a framework for a comparative research agenda to address the question: Under which circumstances and to what extent can private corporations be expected to contribute to public security
Recessive distal renal tubular acidosis in Sarawak caused by AE1 mutations
Mutations of the AE1 (SLC4A1, Anion-Exchanger
1) gene that codes for band 3, the renal and red
cell anion exchanger, are responsible for many cases of
familial distal renal tubular acidosis (dRTA). In Southeast
Asia this disease is usually recessive, caused either by
homozygosity of a single AE1 mutation or by compound
heterozygosity of two different AE1 mutations. We describe
two unrelated boys in Sarawak with dRTA associated
with compound heterozygosity of AE1 mutations.
Both had Southeast Asian ovalocytosis (SAO), a morphological
abnormality of red cells caused by a deletion
of band 3 residues 400â408. In addition, one boy had a
DNA sequence abnormality of band 3 residue (G701D),
which has been reported from elsewhere in Southeast
Asia. The other boy had the novel sequence abnormality
of band 3 (Q759H) and profound hemolytic anemia
C Wright Mills, power and the power elites ? a reappraisal
This paper revisits and presents a critical appraisal of Mills's analysis of power and the power elite. There are signs of a revival of interest in Mills, but recent commentators have shown little interest in the intellectual, social or political context of his analysis. Setting Mills's thesis in its historical context, we consider an element of his project that has been particularly neglected in recent discussion: Mills's search for possible ways of redistributing power and his attempt to forge an ethico-political stance. Reflecting on recent discussion of contemporary elite formations, we comment on what critics might take from Mills in our own time in relation to the analysis of elites and the politics of critical management studies
The deprivation of certitude, legitimacy and hope: foreign national prisoners and the pains of imprisonment
At the end of March 2015 there were 10,481 foreign nationals (defined as non-UK passport holders) held in prisons in England and Wales, representing 12 per cent of the overall prison population. The latest published figures from December 2014 also indicated that there were a further 394 immigration detainees also being held in various prisons, rather than Immigration Removal Centres, across England and Wales. Although Sykesâs deprivation model with its associated âpains of imprisonmentâ has been exhaustively explored by penologists, this article argues that there are a new range of âpainsâ uniquely faced by foreign national prisoners in England and Wales who come under the scrutiny of the Home Officeâs Immigration Service. Drawing on quasi-ethnographic fieldwork in a Specialist Foreign National Prison, this article discusses the new pains relating to a lack of certitude, legitimacy and hope with regard to both their carceral and post-carceral lives
Recovering critique in an age of datafication
This article starts out from the need for critical work on processes of datafication and their consequences for the constitution of social knowledge and the social world. Current social science work on datafication has been greatly shaped by the theoretical approach of Bruno Latour, as reflected in the work of Actor Network Theory and Science and Technology Studies (ANT/STS). The article asks whether this approach, given its philosophical underpinnings, provides sufficient resources for the critical work that is required in relation to datafication. Drawing on Latourâs own reflections about the flatness of the social, it concludes that it does not, since key questions, in particular about the nature of social order cannot be asked or answered within ANT. In the articleâs final section, three approaches from earlier social theory are considered as possible supplements to ANT/STS for a social science serious about addressing the challenges that datafication poses for society
- âŠ